spontaneously hypertensive

Objective: To study the relationship between blood pressure variability ( BPV) and target organs damage ( TOD) in spontaneously hypertensive rats ( SHR) by two antihypertensive drugs, nitrendipine ( Nit) and hydralazine ( Hyd).

目的：用抗高血压药尼群地平（Nit）及肼屈嗪（Hyd）研究血压波动性（BPV）的改变与靶器官损伤（TOD）的关系。

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Materials and methods: We selected respectively 15 spontaneously hypertensive rats ( SHR) and Wistar-Kyoto ( WKY) rats at the age of 12 months, and 10 SHR and WKY rats at the age of 6 weeks in random.

材料与方法：随机选取成年12m龄的自发性高血压大鼠（SHR）和日本京都Wistar（WKY）大鼠各15只，以及幼年6w龄的SHR及WKY大鼠各10只；

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Immunoreactive angiotensin II ( irAII) translated by lymphocyte mRNA from spontaneously hypertensive rats ( SHR) and T lymphosarcoma cells in vitro

自发性高血压大鼠淋巴细胞及T淋巴瘤细胞mRNA体外转译血管紧张素Ⅱ样物质

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The study of apoptosis-associated genes protein in spontaneously hypertensive rats

自发性高血压大鼠细胞凋亡相关基因蛋白的研究

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Changes of activities of fibroblasts derived from spontaneously hypertensive rat

自发性高血压大鼠心脏成纤维细胞生物活性的变化

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Role of the Central Catecholamine System in the Formation of Hypertension in the Spontaneously Hypertensive Rats

大鼠脑内儿茶酚胺系统在高血压形成中的作用

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Objective: To study the effects of YLS on blood pressure ( BP) in normal rats and spontaneously hypertensive rats ( SHR).

目的：研究玉郎伞提取物（YLS）对自发性高血压大鼠（SHR）及正常大鼠血压（BP）的影响。

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Results The syndrome of14-18 week-old spontaneously hypertensive rats appeared to be in accordance with TCM syndrome type "hyperpyrexia of liver syndrome".

结果自发性高血压大鼠在14~18周龄，基本符合高血压中医辨证分型中肝火上炎证型的表现；

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Effect of Compound Danshen Dripping Pills Combined with Fosinopril on Left Ventricular Fibrosis of Spontaneously Hypertensive Rats

复方丹参滴丸与福辛普利联用对自发性高血压大鼠左室纤维化的影响

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The gene expression of kidney in spontaneously hypertensive rat and WKY rat by mRNA differential display

用mRNA差异显示法比较SHR和WKY大鼠肾脏组织的基因表达

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Objective This study was to investigate effects of both compound Danshen dripping pills ( DSP) and the combined use of DSP with fosinopril on left ventricular fibrosis of spontaneously hypertensive rats.

目的探讨复方丹参滴丸（DSP）与福辛普利联用对自发性高血压大鼠（SHR）左室纤维化的影响。

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Changes of β adrenergic receptors and angiotensin ⅱ receptors in spontaneously hypertensive rats and different ages WKY rat hearts

自发性高血压大鼠及不同年龄WKY大鼠心脏β肾上腺素受体和血管紧张素Ⅱ受体的表达

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Aberrant Regulation of Renal Dopamine D_3 Receptor on Sodium Excretion in Salt-loaded Wistar-Kyoto and Spontaneously Hypertensive Rats

肾脏D3受体对盐负荷大鼠尿钠排泄的异常调节在高血压发生中作用

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Expression and Effective of Human Atrial Natriuretic Peptide Gene in Spontaneously Hypertensive Rats

人类心房利钠肽基因在自发性高血压大鼠体内表达及其影响

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AIM: To observe the effect of tanshinone ⅱ A ( TSN-ⅱ A) on myocardial cell apoptosis protein of spontaneously hypertensive rats with left ventricular hypertrophy.

目的：观察丹参的脂溶性成分丹参酮ⅡA对自发性高血压大鼠左室肥厚心肌凋亡蛋白的作用。方法：实验于2005-03/2005-07在华中科技大学同济医学院急诊科实验室完成。

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Relationship between tgf-β_1 and renal function in spontaneously hypertensive rats

TGF-β1与自发性高血压大鼠肾脏功能关系的研究

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The accumulation of inositol phosphates ( IPs) was measured by the method of 3H-inositol incorporation in aortae isolated from stroke prone spontaneously hypertensive ( SHRsp) rats and WKY rats.

采用~3H-肌醇参入方法测定易卒中型自发性高血压（SHR~（SP））大鼠与WKY大鼠离体主动脉磷酸肌醇（IPs）的蓄积。

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Human Atrial Natriuretic Peptide Gene Delivery Reduces Blood Pressure in Young Spontaneously Hypertensive Rats

人类心房利钠肽基因对幼龄自发性高血压大鼠的降压作用

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An Experimental Study on Free Radical Retinal Damage in the Spontaneously Hypertensive Rats

自发性高血压大鼠视网膜自由基损伤的实验研究

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Effect of the chloride channel activity on vascular tone in the spontaneously hypertensive rats

Cl~-通道活动对自发性高血压大鼠血管张力的影响

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The Study of Erythrocyte Membrane ATPase Activity in Spontaneously Hypertensive Rats

自发性高血压大鼠红细胞膜ATP酶活性的研究

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Cardiovascular Effects Mediated by GABA_B Receptor in the Rostral Ventrolateral Medulla of Spontaneously Hypertensive Rats

高血压大鼠延髓头端腹外侧区GABA B受体中介的心血管效应

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AIM: To detect different expression of pre-proenkephalin mRNA ( PPE mRNA) in 16-wk-old spontaneously hypertensive rat ( SHR) and age-matched normotensive Wistar-Kyoto rat ( WKY).

目的：检测前脑啡肽原信使RNA（PPE mRNA）在16周自发性高血压大鼠（SHR）和Wistar-Kyoto大鼠（WKY）中的不同表达。

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Morphological study on remodeling of the aortic arch in spontaneously hypertensive rats

自发性高血压大鼠主动脉弓重建的形态学研究

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Thromboxane A2 and Prostacyclin and the Development of Hypertension in Spontaneously Hypertensive Rats Role of the Central Catecholamine System in the Formation of Hypertension in the Spontaneously Hypertensive Rats

自发性高血压大鼠血浆TXA2和前列腺环素的变化大鼠脑内儿茶酚胺系统在高血压形成中的作用

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Objective: To observe the effects of atorvastatin calcium on systolic blood pressure ( SBP), left ventricular function and the change of left ventricular hypertrophy in spontaneously hypertensive rats ( SHR) and investigate the mechanism of this functional changes.

目的：以原发性高血压大鼠（Spontaneously Hypertensive Rats，SHR）为实验模型，观察单纯使用阿托伐他汀钙对SHR血压、左室功能的影响，并探讨其相关机制。

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Methods 34 male 12-week-old spontaneously hypertensive rats ( SHR) and Wistar-Kyoto ( WKY) rats were injected anti-ICAM-1 monoclonal antibody and distilled water by cauda vein for 12 weeks, respectively.

方法12周龄雄性WKY大鼠和自发性高血压大鼠（SHR）共34只，分为对照组、高血压组、抗ICAM-1抗体治疗组。抗ICAM-1抗体治疗组经尾静脉注射抗ICAM-1单克隆抗体12周。

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AIM and METHODS: The level of insulin-like growth factor-ⅰ ( IGF-ⅰ) in heart tissues of spontaneously hypertensive rats ( SHR) and Wistar-Kyoto rats ( WKY) was measured by radioimmunoassay.

目的和方法：采用放射免疫分析法测定自发性高血压大鼠（SHR）和正常血压大鼠（WKY）心肌组织中胰岛素样生长因子Ⅰ（IGF－I）水平。

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CONCLUSION: Long-term usage of TSN can inhibit the development of LVH in spontaneously hypertensive rats. The mechanism may be related with up-regulating the expression of Bcl-2 and down-regulating the expression of Bax and p53 by TSN-ⅱ A.

结论：长期应用丹参酮ⅡA治疗可预防自发性高血压大鼠左室肥厚的形成，其机制可能与丹参酮ⅡA上调心肌细胞凋亡蛋白Bcl-2、下调Bax蛋白及抑制p53蛋白的表达有关。

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It was verified in our previous study that endothelium-dependent relaxation ( EDR) in the mesenteric artery strip of adult spontaneously hypertensive rats ( SHR and SHRsp) was decreased upon addition of acetylcholine ( ACh).

我们以往的工作证实成年自发高血压大鼠（SHR与SHRsp）肠系膜动脉由乙酰胆碱引起的内皮依赖性舒张（EDR）减弱。

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